Osteoclasts: Multifaceted Molecule in Vesicular Trafficking
Published: August 1, 2019 | DOI: https://doi.org/10.7860/JCDR/2019/40307.13064
Anil Kumar Kanakamedala, Jaideep Mahendra, Nashra Kareem, Little Mahendra
1. Associate Professor, Department of Periodontics, Faculty of Dentistry, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India.
2. Professor and Director of PG Studies, Department of Periodontics, Faculty of Dentistry, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India.
3. Senior Lecturer, Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India.
4. Dean and Head of Research, Department of Periodontics, Maktoum Bin Hamdan Dental College, Dubai, United Arab Emirates.
Correspondence
Dr. Jaideep Mahendra,
Department of Periodontics, Faculty of Dentistry, Meenakshi Academy of Higher Education and Research, No. 1,
Alapakkam Main Road, Maduravoyal, Chennai-600095, Tamil Nadu, India.
E-mail: jaideep_m_23@yahoo.co.in
It has been widely accepted that periodontitis is a result of the host immune inflammatory response caused by various periodontal microorganisms leading to tissue degradation and bone resorption. One important mechanism of the inflammatory mediators present in periodontal tissue is the stimulation and formation of osteoclasts that are believed to be the major cell type responsible for bone resorption. This review article comprehensively explains the various molecular activities of osteoclasts and their role in periodontitis.
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